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Ponatinib Hydrochloride
CAS No. 1114544-31-8
Ponatinib Hydrochloride( —— )
Catalog No. M33966 CAS No. 1114544-31-8
Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 37 | Get Quote |
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| 25MG | 66 | Get Quote |
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| 50MG | 104 | Get Quote |
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| 100MG | 155 | Get Quote |
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| 200MG | 230 | Get Quote |
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| 500MG | 390 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePonatinib Hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPonatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib.
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DescriptionPonatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. Ponatinib (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetSrc
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RecptorSrc | PDGFR | VEGFR | FGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number1114544-31-8
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Formula Weight569.02
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Molecular FormulaC29H28ClF3N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (43.94 mM; Ultrasonic (<60°C)
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SMILESCl.CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412.?
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